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Article

Usp22 deficiency impairs intestinal epithelial lineage specification in vivo.

Oncotarget - 10 Nov 2015

Kosinsky Robyn L, Wegwitz Florian, Hellbach Nicole, Dobbelstein Matthias, Mansouri Ahmed, Vogel Tanja, Begus-Nahrmann Yvonne, Johnsen Steven A

Abstract excerpt

Epigenetic regulatory mechanisms play a central role in controlling gene expression during development, cell differentiation and tumorigenesis. Monoubiquitination of histone H2B is one epigenetic modification which is dynamically regulated by the opposing activities of specific ubiquitin ligases and deubiquitinating enzymes (DUBs). The Ubiquitin-specific Protease 22 (USP22) is the ubiquitin hydrolase component of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26431380
DOI: 10.18632/oncotarget.5412
PMCID: PMC4741973

Genes

USP22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Usp22 deficiency impairs intestinal epithelial lineage specification in vivo.PMID 26431380Read ↗

USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placentaSemantic proximity Read ↗

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Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in CancerSemantic proximity Read ↗

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Embryonic demise caused by targeted disruption of a cysteine protease Dub-2.Semantic proximity Read ↗

USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.Semantic proximity Read ↗

USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic DevelopmentSemantic proximity Read ↗

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