Article
USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.
The Journal of biological chemistry - 10 Mar 2017
Fraile Julia M, Manchado Eusebio, Lujambio Amaia, Quesada Víctor, Campos-Iglesias Diana, Webb Thomas R, Lowe Scott W, López-Otín Carlos, Freije José M P
Abstract excerpt
KRAS is the most frequently mutated oncogene in human cancer, but its therapeutic targeting remains challenging. Here, we report a synthetic lethal screen with a library of deubiquitinases and identify USP39, which encodes an essential splicing factor, as a critical gene for the viability of KRAS-dependent cells. We show that splicing fidelity inhibitors decrease preferentially the proliferation rate of...
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