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Article

USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.

The Journal of biological chemistry - 10 Mar 2017

Fraile Julia M, Manchado Eusebio, Lujambio Amaia, Quesada Víctor, Campos-Iglesias Diana, Webb Thomas R, Lowe Scott W, López-Otín Carlos, Freije José M P

Abstract excerpt

KRAS is the most frequently mutated oncogene in human cancer, but its therapeutic targeting remains challenging. Here, we report a synthetic lethal screen with a library of deubiquitinases and identify USP39, which encodes an essential splicing factor, as a critical gene for the viability of KRAS-dependent cells. We show that splicing fidelity inhibitors decrease preferentially the proliferation rate of...

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Source

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Identifiers

PMID: 28154181
DOI: 10.1074/jbc.M116.762757
PMCID: PMC5354494

Genes

USP39
KRAS
DHX38

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.PMID 28154181Read ↗

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies.Semantic proximity Read ↗

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Targeting USP47 enhances the efficacy of KRAS inhibitor in KRASG12C mutated non-small cell lung cancer by controlling deubiquitination of c-Myc.Semantic proximity Read ↗

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DDX39B contributes to the proliferation of colorectal cancer through direct binding to CDK6/CCND1Semantic proximity Read ↗

Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer.Semantic proximity Read ↗

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USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.Semantic proximity Read ↗

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