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Article

USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression

6 Nov 2013

Abstract excerpt

Increasing evidence links deregulation of the ubiquitin-specific proteases 22 (USP22) deubitiquitylase to cancer development and progression in a select group of tumor types, but its specificity and underlying mechanisms of action are not well defined. Here we show that USP22 is a critical promoter of lethal tumor phenotypes that acts by modulating nuclear receptor and oncogenic signaling. In multiple xenograft...

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PMID: 24197134
DOI: 10.1158/0008-5472.can-13-1954

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