Article
Differential strengths of molecular determinants guide environment specific mutational fates.
PLoS genetics - 1 May 2018
Dandage Rohan, Pandey Rajesh, Jayaraj Gopal, Rai Manish, Berger David, Chakraborty Kausik
Abstract excerpt
Organisms maintain competitive fitness in the face of environmental challenges through molecular evolution. However, it remains largely unknown how different biophysical factors constrain molecular evolution in a given environment. Here, using deep mutational scanning, we quantified empirical fit...
Topics
- Acetyltransferases
- Adaptation, Biological
- DNA Mutational Analysis
- Drug Resistance, Bacterial
- Environment
- Escherichia coli
- Escherichia coli Proteins
- Evolution, Molecular
- Gentamicins
- High-Throughput Nucleotide Sequencing
- Ligands
- Microbial Sensitivity Tests
- Mutagenesis, Site-Directed
- Mutation
- Protein Folding
- Protein Stability
- Temperature