Article
Capturing the mutational landscape of the beta-lactamase TEM-1.
Proceedings of the National Academy of Sciences of the United States of America - 6 Aug 2013
Jacquier Hervé, Birgy André, Le Nagard Hervé, Mechulam Yves, Schmitt Emmanuelle, Glodt Jérémy, Bercot Beatrice, Petit Emmanuelle, Poulain Julie, Barnaud Guilène, Gros Pierre-Alexis, Tenaillon Olivier
Abstract excerpt
Adaptation proceeds through the selection of mutations. The distribution of mutant fitness effect and the forces shaping this distribution are therefore keys to predict the evolutionary fate of organisms and their constituents such as enzymes. Here, by producing and sequencing a comprehensive collection of 10,000 mutants, we explore the mutational landscape of one enzyme involved in the spread of antibiotic...
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