Article

Function-specific epistasis shapes evolutionary trajectories towards antibiotic resistance

2025-07-12

Abstract excerpt

Pre-existing mutations can influence subsequent evolution by constraining or opening evolutionary pathways through epistatic interactions. In some cases, global epistasis allows evolutionary pathways to be predicted from the fitness of the genetic background alone. In other cases, idiosyncratic epistasis makes evolution less predictable. Here, we show that the evolution of antibiotic resistance is highly repeatabl...

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Literature Corpus work: d55f3e9d-c76f-5c8f-8a77-82e0ec81826e
DOI: 10.1101/2025.07.09.663857

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