Article
Quantitative Description of a Protein Fitness Landscape Based on Molecular Features.
Molecular biology and evolution - 1 Jul 2015
Meini María-Rocío, Tomatis Pablo E, Weinreich Daniel M, Vila Alejandro J
Abstract excerpt
Understanding the driving forces behind protein evolution requires the ability to correlate the molecular impact of mutations with organismal fitness. To address this issue, we employ here metallo-β-lactamases as a model system, which are Zn(II) dependent enzymes that mediate antibiotic resistance. We present a study of all the possible evolutionary pathways leading to a metallo-β-lactamase variant optimized by...
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