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Article

Biophysical principles predict fitness landscapes of drug resistance.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 2016

Rodrigues João V, Bershtein Shimon, Li Anna, Lozovsky Elena R, Hartl Daniel L, Shakhnovich Eugene I

Abstract excerpt

Fitness landscapes of drug resistance constitute powerful tools to elucidate mutational pathways of antibiotic escape. Here, we developed a predictive biophysics-based fitness landscape of trimethoprim (TMP) resistance for Escherichia coli dihydrofolate reductase (DHFR). We investigated the activity, binding, folding stability, and intracellular abundance for a complete set of combinatorial DHFR mutants made out...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epistasis, Genetic

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Source

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Identifiers

PMID: 26929328
DOI: 10.1073/pnas.1601441113
PMCID: PMC4801265

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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