Article

Chromatoid body integrates piRNA, SMG6 and m⁶A pathways to control mRNAs in the male germline

2026-03-28

Abstract excerpt

<h4>ABSTRACT</h4> Spermatogenesis requires tightly controlled transcriptome regulation, supported by the PIWI-interacting RNA (piRNA) and nonsense-mediated decay (NMD) pathways, both concentrated in the chromatoid body (CB) of haploid spermatids. We previously showed that the NMD endonuclease SMG6 interacts with the piRNA-binding protein PIWIL1, and that loss of either factor results in overlapping mRNA dysregula...

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Literature Corpus work: 8fb2eb3b-867f-5c11-8478-c76f17f3e326
DOI: 10.64898/2026.03.26.714452

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