Article

Bi-allelic variants in <i>TBC1D8</i> result in non-obstructive azoospermia in both humans and mice

2025-11-06

Abstract excerpt

<h4> Abstract </h4> Non-obstructive azoospermia (NOA) is a severe form of male infertility. Proteins from the Tre2-Bub2-Cdc16 (TBC) family emerge as key contributors to spermatogenesis, including TBC1D20, TBC1D21, and TBC1D25. Nonetheless, the specific role of TBC1D8 in male male fertility remains unclear. Our study aims to elucidate the relationship between TBC1D8 and male infertility in humans and mice. Male...

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Literature Corpus work: d4000c4b-4f19-510c-a89a-930cf8f77760
DOI: 10.1101/2025.10.31.25337980

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