Article

Maternal factor PABPN1L is essential for maternal mRNA degradation during maternal-to-zygotic transition

2020-08-20

Abstract excerpt

Infertility affects 10% - 15% of families worldwide. However, the pathogenesis of female infertility caused by abnormal early embryonic development is not clear. We constructed a mouse model (Pabpn1l -/-) simulating the splicing abnormality of human PABPN1L and found that the female was sterile and the male was fertile. The Pabpn1l -/- oocytes can be produced, ovulated and fertilized normally, but cannot develop b...

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Literature Corpus work: 1300e3e3-e1a2-55c0-9554-9918c3146117
DOI: 10.1101/2020.08.20.258830

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