Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Circulating CD4+CD8+ double-positive T-cells display features of innate and adaptive immune function in granulomatosis with polyangiitis.

Clinical and experimental rheumatology - 1 Jan 2000

Kerstein Anja, Müller Antje, Pitann Silke, Riemekasten Gabriela, Lamprecht Peter

Abstract excerpt

OBJECTIVES: To examine functional features of CD4+CD8+ double-positive T-cells in patients with granulomatosis with polyangiitis (GPA) using phenotypic and transcriptomic analysis. METHODS: Staining of cellular surface marker was performed using freshly collected whole blood. For intracellular cytokine staining freshly collected whole blood was stimulated with phorbol myristate acetate and ionomycin. Multicolor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptive Immunity
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Granulomatosis with Polyangiitis

Share to T-Lymphocyte Subsets

Share to Th1 Cells

Share to Th17 Cells

Share to Th2 Cells

Source

Identifiers

PMID: 29799396

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Circulating CD4+CD8+ double-positive T-cells display features of innate and adaptive immune function in granulomatosis with polyangiitis.PMID 29799396Read ↗

Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis.Semantic proximity Read ↗

Single-cell multi-omics analysis identifies two distinct phenotypes of newly-onset microscopic polyangiitisSemantic proximity Read ↗

CD8+ T Cells in GCA and GPA: Bystanders or Active Contributors?Semantic proximity Read ↗

Single-cell multi-omics analysis identifies two distinct phenotypes of newly-onset microscopic polyangiitis.Semantic proximity Read ↗

Active but not inactive granulomatosis with polyangiitis is associated with decreased and phenotypically and functionally altered CD56(dim) natural killer cells.Semantic proximity Read ↗

Increased miR-142-3p Expression Might Explain Reduced Regulatory T Cell Function in Granulomatosis With PolyangiitisSemantic proximity Read ↗

Identification of key genes and imbalance of immune cell infiltration in immunoglobulin A associated vasculitis nephritis by integrated bioinformatic analysisSemantic proximity Read ↗

Peripheral T cell populations are differentially affected in monogenic autoinflammatory syndromes and goutSemantic proximity Read ↗

T helper cell dysfunction in ANCA associated vasculitisSemantic proximity Read ↗

Immune stimulatory effects of neutrophil extracellular traps in granulomatosis with polyangiitis.Semantic proximity Read ↗

Aberrant phenotype of circulating antigen presenting cells in giant cell arteritis and polymyalgia rheumaticaSemantic proximity Read ↗

Phenotypic, transcriptomic and functional profiling reveal reduced activation thresholds of CD8+ T cells in giant cell arteritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.