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Article

Phenotypic, transcriptomic and functional profiling reveal reduced activation thresholds of CD8+ T cells in giant cell arteritis.

Rheumatology (Oxford, England) - 23 Dec 2022

Reitsema Rosanne D, van der Geest Kornelis S M, Sandovici Maria, Jiemy William F, Graver Jacoba C, Abdulahad Wayel H, Boots Annemieke M H, Heeringa Peter, Brouwer Elisabeth

Abstract excerpt

OBJECTIVES: Evidence from temporal artery tissue and blood suggests involvement of CD8+ T cells in the pathogenesis of GCA, but their exact role is poorly understood. Therefore, we performed a comprehensive analysis of circulating and lesional CD8+ T cells in GCA patients. METHODS: Circulating CD8+ T cells were analysed for differentiation status (CD45RO, CCR7), markers of activation (CD69 and CD25) and...

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Identifiers

PMID: 35460236
DOI: 10.1093/rheumatology/keac250
PMCID: PMC9788826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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