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Article

Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis.

Journal of autoimmunity - 1 Mar 2017

Kerstein Anja, Schüler Silke, Cabral-Marques Otávio, Fazio Juliane, Häsler Robert, Müller Antje, Pitann Silke, Moosig Frank, Klapa Sebastian, Haas Christian, Kabelitz Dieter, Riemekasten Gabriela, Wolters Steffen, Lamprecht Peter

Abstract excerpt

Autoimmune diseases are initiated by a combination of predisposing genetic and environmental factors resulting in self-perpetuating chronic inflammation and tissue damage. Autoantibody production and an imbalance of effector and regulatory T-cells are hallmarks of autoimmune dysregulation. While expansion of circulating effector memory T-cells is linked to disease pathogenesis and progression, the causes driving...

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Cytomegalovirus Infections
Environment
Epstein-Barr Virus Infections
Granulomatosis with Polyangiitis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocyte Activation

Lymphocyte Count

T-Lymphocyte Subsets

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PMID: 28040323
DOI: 10.1016/j.jaut.2016.12.004

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