Article

T helper cell dysfunction in ANCA associated vasculitis

2020-01-01

Abstract excerpt

Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is an autoimmune disease characterised by inflammation of small blood vessels that leads to organ dysfunction. Auto-reactive B cells produce pathogenic antibodies against the neutrophil enzymes, myeloperoxidase (MPO) and proteinase 3 (PR3). Genome-wide association studies that identified the relationship between MHC class II genes and ANCA spe...

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Literature Corpus work: ca158bc5-78a2-5bff-9495-2c2e9f8e0438
DOI: 10.17863/cam.65670

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