Article
Single-cell multi-omics analysis identifies two distinct phenotypes of newly-onset microscopic polyangiitis.
Nature communications - 11 Oct 2023
Nishide Masayuki, Nishimura Kei, Matsushita Hiroaki, Edahiro Ryuya, Inukai Sachi, Shimagami Hiroshi, Kawada Shoji, Kato Yasuhiro, Kawasaki Takahiro, Tsujimoto Kohei, Kamon Hokuto, Omiya Ryusuke, Okada Yukinori, Hattori Kunihiro, Narazaki Masashi, Kumanogoh Atsushi
Abstract excerpt
The immunological basis of the clinical heterogeneity in autoimmune vasculitis remains poorly understood. In this study, we conduct single-cell transcriptome analyses on peripheral blood mononuclear cells (PBMCs) from newly-onset patients with microscopic polyangiitis (MPA). Increased proportions of activated CD14+ monocytes and CD14+ monocytes expressing interferon signature genes (ISGs) are distinctive features...
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