Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription.

Retrovirology - 23 May 2018

Ivanov Andrey, Lin Xionghao, Ammosova Tatiana, Ilatovskiy Andrey V, Kumari Namita, Lassiter Hatajai, Afangbedji Nowah, Niu Xiaomei, Petukhov Michael G, Nekhai Sergei

Abstract excerpt

BACKGROUND: HIV-1 transcription activator protein Tat is phosphorylated in vitro by CDK2 and DNA-PK on Ser-16 residue and by PKR on Tat Ser-46 residue. Here we analyzed Tat phosphorylation in cultured cells and its functionality. RESULTS: Mass spectrometry analysis showed primarily Tat Ser-16 phosphorylation in cultured cells. In vitro, CDK2/cyclin E predominantly phosphorylated Tat Ser-16 and PKR-Tat Ser-46....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase 2
Share to eIF-2 Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to Gene Knockdown Techniques

Share to Host-Pathogen Interactions

Share to Serine

Share to tat Gene Products, Human Immunodeficiency Virus

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 29792216
DOI: 10.1186/s12977-018-0422-5
PMCID: PMC5966876

Genes

CDK2
CDK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription.PMID 29792216Read ↗

Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription.Semantic proximity Read ↗

DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTRSemantic proximity Read ↗

Phosphorylation of the VP16 transcriptional activator protein during herpes simplex virus infection and mutational analysis of putative phosphorylation sites.Semantic proximity Read ↗

Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes.Semantic proximity Read ↗

DNA-PK facilitates HIV transcription by regulating the activity of RNA polymerase II and the recruitment of transcription machinery at HIV LTRSemantic proximity Read ↗

Phosphorylation regulates human T-cell leukemia virus type 1 Rex function.Semantic proximity Read ↗

CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90.Semantic proximity Read ↗

Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein.Semantic proximity Read ↗

HIV-1 Tat potently stabilises Mdm2 and enhances viral replication.Semantic proximity Read ↗

Conserved Mitotic Phosphorylation of a Proteasome Subunit Regulates Cell Proliferation.Semantic proximity Read ↗

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting.Semantic proximity Read ↗

MX2 viral substrate breadth and inhibitory activity are regulated by protein phosphorylationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.