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Article

HIV-1 Tat potently stabilises Mdm2 and enhances viral replication.

The Biochemical journal - 11 Jul 2017

Raja Rameez, Ronsard Larance, Lata Sneh, Trivedi Shubhendu, Banerjea Akhil C

Abstract excerpt

Murine double minute 2 (Mdm2) is known to enhance the transactivation potential of human immunodeficiency virus (HIV-1) Tat protein by causing its ubiquitination. However, the regulation of Mdm2 during HIV-1 infection and its implications for viral replication have not been well studied. Here, we show that the Mdm2 protein level increases during HIV-1 infection and this effect is mediated by HIV-1 Tat protein....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28468838
DOI: 10.1042/BCJ20160825
PMCID: PMC5509382

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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