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Article

Collecting duct principal, but not intercalated, cell prorenin receptor regulates renal sodium and water excretion.

American journal of physiology. Renal physiology - 1 Sept 2018

Ramkumar Nirupama, Stuart Deborah, Mironova Elena, Abraham Nikita, Gao Yang, Wang Shuping, Lakshmipathi Jayalakshmi, Stockand James D, Kohan Donald E

Abstract excerpt

The collecting duct is the predominant nephron site of prorenin and prorenin receptor (PRR) expression. We previously demonstrated that the collecting duct PRR regulates epithelial Na+ channel (ENaC) activity and water transport; however, which cell type is involved remains unclear. Herein, we examined the effects of principal cell (PC) or intercalated cell (IC) PRR deletion on renal Na+ and water handling. PC or...

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Identifiers

PMID: 29790390
DOI: 10.1152/ajprenal.00122.2018
PMCID: PMC6172572

Genes

AQP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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