Article
Renal collecting duct NOS1 maintains fluid-electrolyte homeostasis and blood pressure.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 2013
Hyndman Kelly A, Boesen Erika I, Elmarakby Ahmed A, Brands Michael W, Huang Paul, Kohan Donald E, Pollock David M, Pollock Jennifer S
Abstract excerpt
Nitric oxide is a pronatriuretic and prodiuretic factor. The highest renal NO synthase (NOS) activity is found in the inner medullary collecting duct. The collecting duct (CD) is the site of daily fine-tune regulation of sodium balance, and led us to hypothesize that a CD-specific deletion of NOS1 would result in an impaired ability to excrete a sodium load leading to a salt-sensitive blood pressure phenotype. We...
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