Article
Blood Pressure Elevation of Tubular Specific (P)RR Transgenic Mice and Lethal Tubular Degeneration due to Possible Intracellular Interactions between (P)RR and Alternative Renin Products.
International journal of molecular sciences - 28 Dec 2021
Saigo Sae, Kino Tabito, Uchida Kotaro, Sugawara Takuya, Chen Lin, Sugiyama Michiko, Azushima Kengo, Wakui Hiromichi, Tamura Kouichi, Ishigami Tomoaki
Abstract excerpt
The prorenin/renin receptor ((P)RR) is a multifunctional protein that is widely distributed in various organs. Despite intensive research for more than 20 years, this receptor has not been fully characterized. In this study, we generated mice overexpressing the tubular epithelial (P)RR gene ((P)RR-TG mice) to test the previously reported functional role of (P)RR by Ramkumar et al. in 2015 using tubular specific...
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