Article
Transcriptional regulator RBP-J regulates the number and plasticity of renin cells.
Physiological genomics - 8 Sept 2011
Castellanos Rivera Ruth M, Monteagudo Maria C, Pentz Ellen S, Glenn Sean T, Gross Kenneth W, Carretero Oscar, Sequeira-Lopez Maria Luisa S, Gomez R Ariel
Abstract excerpt
Renin-expressing cells are crucial in the control of blood pressure and fluid-electrolyte homeostasis. Notch receptors convey cell-cell signals that may regulate the renin cell phenotype. Because the common downstream effector for all Notch receptors is the transcription factor RBP-J, we used a conditional knockout approach to delete RBP-J in cells of the renin lineage. The resultant RBP-J conditional knockout...
Topics
- Animals
- Cells, Cultured
- Genotype
- Immunoglobulin J Recombination Signal Sequence-Binding Protein
- Immunohistochemistry
- Juxtaglomerular Apparatus
- Mice
- Mice, Knockout
- RNA, Messenger
- Renin
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction