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Article

Transcriptional regulator RBP-J regulates the number and plasticity of renin cells.

Physiological genomics - 8 Sept 2011

Castellanos Rivera Ruth M, Monteagudo Maria C, Pentz Ellen S, Glenn Sean T, Gross Kenneth W, Carretero Oscar, Sequeira-Lopez Maria Luisa S, Gomez R Ariel

Abstract excerpt

Renin-expressing cells are crucial in the control of blood pressure and fluid-electrolyte homeostasis. Notch receptors convey cell-cell signals that may regulate the renin cell phenotype. Because the common downstream effector for all Notch receptors is the transcription factor RBP-J, we used a conditional knockout approach to delete RBP-J in cells of the renin lineage. The resultant RBP-J conditional knockout...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21750232
DOI: 10.1152/physiolgenomics.00061.2011
PMCID: PMC3180736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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