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Article

Prorenin receptor controls renal branching morphogenesis via Wnt/β-catenin signaling.

American journal of physiology. Renal physiology - 1 Mar 2017

Song Renfang, Janssen Adam, Li Yuwen, El-Dahr Samir, Yosypiv Ihor V

Abstract excerpt

The prorenin receptor (PRR) is a receptor for renin and prorenin, and an accessory subunit of the vacuolar proton pump H+-ATPase. Renal branching morphogenesis, defined as growth and branching of the ureteric bud (UB), is essential for mammalian kidney development. Previously, we demonstrated that conditional ablation of the PRR in the UB in PRRUB-/- mice causes severe defects in UB branching, resulting in marked...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28031172
DOI: 10.1152/ajprenal.00563.2016

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