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Article

Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype.

Pflugers Archiv : European journal of physiology - 1 May 2016

Canonica Jérémie, Sergi Chloé, Maillard Marc, Klusonova Petra, Odermatt Alex, Koesters Robert, Loffing-Cueni Dominique, Loffing Johannes, Rossier Bernard, Frateschi Simona, Hummler Edith

Abstract excerpt

Aldosterone is the main mineralocorticoid hormone controlling sodium balance, fluid homeostasis, and blood pressure by regulating sodium reabsorption in the aldosterone-sensitive distal nephron (ASDN). Germline loss-of-function mutations of the mineralocorticoid receptor (MR) in humans and in mice lead to the "renal" form of type 1 pseudohypoaldosteronism (PHA-1), a case of aldosterone resistance characterized by...

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Identifiers

PMID: 26762397
DOI: 10.1007/s00424-015-1785-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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