Article
Collecting duct prorenin receptor knockout reduces renal function, increases sodium excretion, and mitigates renal responses in ANG II-induced hypertensive mice.
American journal of physiology. Renal physiology - 1 Dec 2017
Prieto Minolfa C, Reverte Virginia, Mamenko Mykola, Kuczeriszka Marta, Veiras Luciana C, Rosales Carla B, McLellan Matthew, Gentile Oliver, Jensen V Behrana, Ichihara Atsuhiro, McDonough Alicia A, Pochynyuk Oleh M, Gonzalez Alexis A
Abstract excerpt
Augmented intratubular angiotensin (ANG) II is a key determinant of enhanced distal Na+ reabsorption via activation of epithelial Na+ channels (ENaC) and other transporters, which leads to the development of high blood pressure (BP). In ANG II-induced hypertension, there is increased expression of the prorenin receptor (PRR) in the collecting duct (CD), which has been implicated in the stimulation of the sodium...
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