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Article

Highly tamoxifen-inducible principal cell-specific Cre mice with complete fidelity in cell specificity and no leakiness.

American journal of physiology. Renal physiology - 1 Apr 2018

Chen Lihe, Gao Chao, Zhang Long, Zhang Ye, Chen Enuo, Zhang Wenzheng

Abstract excerpt

An ideal inducible system should be cell specific and have absolutely no background recombination without induction (i.e., no leakiness), a high recombination rate after induction, and complete fidelity in cell specificity (i.e., restricted recombination exclusively in cells where the driver gene is expressed). However, such an ideal mouse model remains unavailable for collecting duct research. Here, we report a...

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PMID: 29357435
DOI: 10.1152/ajprenal.00436.2017
PMCID: PMC5966762

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