Article
White Matter Microstructure in Bipolar Disorder Is Influenced by the Interaction between a Glutamate Transporter EAAT1 Gene Variant and Early Stress.
Molecular neurobiology - 1 Jan 2019
Poletti Sara, Bollettini Irene, Lorenzi Cristina, Vitali Alice, Brioschi Silvia, Serretti Alessandro, Colombo Cristina, Benedetti Francesco
Abstract excerpt
Glutamate is the principal excitatory neurotransmitter in the central nervous system. In mature brains, it is critically involved in neuroplasticity and, at high levels, neurotoxicity. The concentrations of glutamate in the extracellular space are maintained at low physiological levels by molecular glutamate transporters (excitatory amino acid transporters-EAATs). Adverse childhood experiences (ACEs) are highly...
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