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Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function

9 Aug 2016

Abstract excerpt

Rare genetic variants of large effect can help elucidate the pathophysiology of brain disorders. Here we expand the clinical and genetic analyses of a family with a (1;11)(q42;q14.3) translocation multiply affected by major psychiatric illness and test the effect of the translocation on the structure and function of prefrontal, and temporal brain regions. The translocation showed significant linkage (LOD score...

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PMID: 27602385
DOI: 10.1038/npjschz.2016.24

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