Article
Behavioural and molecular endophenotypes in psychotic disorders reveal heritable abnormalities in glutamatergic neurotransmission.
Translational psychiatry - 31 Mar 2015
Scoriels L, Salek R M, Goodby E, Grainger D, Dean A M, West J A, Griffin J L, Suckling J, Nathan P J, Lennox B R, Murray G K, Bullmore E T, Jones P B
Abstract excerpt
Psychotic disorders such as schizophrenia are biologically complex and carry huge population morbidity due to their prevalence, persistence and associated disability. Defined by features such as delusions and hallucinations, they involve cognitive dysfunction and neurotransmitter dysregulations that appear mostly to involve the dopaminergic and glutamatergic systems. A number of genetic and environmental factors...
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