Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Programming cells by multiplex genome engineering and accelerated evolution.

Nature - 13 Aug 2009

Wang Harris H, Isaacs Farren J, Carr Peter A, Sun Zachary Z, Xu George, Forest Craig R, Church George M

Abstract excerpt

The breadth of genomic diversity found among organisms in nature allows populations to adapt to diverse environments. However, genomic diversity is difficult to generate in the laboratory and new phenotypes do not easily arise on practical timescales. Although in vitro and directed evolution methods have created genetic variants with usefully altered phenotypes, these methods are limited to laborious and serial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotechnology
Share to Carotenoids
Share to Chromosomes, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Directed Molecular Evolution

Share to Escherichia coli

Share to Genome, Bacterial

Share to Lycopene

Source

Open in PubMed Open full text

Identifiers

PMID: 19633652
DOI: 10.1038/nature08187
PMCID: PMC4590770

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Programming cells by multiplex genome engineering and accelerated evolution.PMID 19633652Read ↗

Genomes by design.Semantic proximity Read ↗

Multiplex genome editing by natural transformation.Semantic proximity Read ↗

Selection of chromosomal DNA libraries using a multiplex CRISPR system.Semantic proximity Read ↗

Multiplexed tracking of combinatorial genomic mutations in engineered cell populations.Semantic proximity Read ↗

The evolving art of creating genetic diversity: From directed evolution to synthetic biology.Semantic proximity Read ↗

Rapid editing and evolution of bacterial genomes using libraries of synthetic DNA.Semantic proximity Read ↗

Genetic engineering: CREATE-ing genome-wide designed mutations.Semantic proximity Read ↗

Tools for genome-wide strain design and construction.Semantic proximity Read ↗

Streamlining genomes: toward the generation of simplified and stabilized microbial systems.Semantic proximity Read ↗

Multiplexed genome engineering and genotyping methods applications for synthetic biology and metabolic engineering.Semantic proximity Read ↗

Rapid pathway prototyping and engineering using in vitro and in vivo synthetic genome SCRaMbLE-in methods.Semantic proximity Read ↗

High-throughput functional variant screens via in vivo production of single-stranded DNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.