Article
Variants in genes coding for glutathione S-transferases and asthma outcomes in children.
Pharmacogenomics - 1 Jun 2018
Turner Steve, Francis Ben, Wani Nuha, Vijverberg Susanne, Pino-Yanes Maria, Mukhopadhyay Somnath, Tavendale Roger, Palmer Colin, Burchard Esteban G, Merid Simon Kebede, Melén Erik, Maitland-van der Zee Anke H, The Pharmacogenomics In Childhood Asthma Consortium On Behalf Of
Abstract excerpt
Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three cohorts (2362 children). GSTT1 null (but...
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