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Article

Genetic alterations of glutathione S-transferases in asthma: do they modulate lung growth and response to environmental stimuli?

Allergy and asthma proceedings - 1 Jan 2000

Sampsonas Fotis, Archontidou Maria-Antigoni, Salla Eugenia, Karkoulias Kiriakos, Tsoukalas George, Spiropoulos Kostas

Abstract excerpt

Glutathione S-transferases (GSTs) constitute a super family of dimeric phase II metabolic enzymes that catalyze the conjugation of reduced glutathione with various electrophilic compounds and reactive oxygen species (ROS). Failure to detoxify ROS, as a sequel of altered GST genotype is able to aggravate the inflammatory cascade, promote bronchoconstrictor mechanisms, activate asthma-like symptomatology, and...

Topics

Alleles
Asthma
Glutathione Transferase
Humans
Lung

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 17619555
DOI: 10.2500/aap.2007.28.3002

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