Article
The association of maternal but not paternal genetic variation in GSTP1 with asthma phenotypes in children.
Respiratory medicine - 1 Dec 2003
Child Frances, Lenney Warren, Clayton Sadie, Davies Siobhan, Jones Peter W, Alldersea Julie E, Strange Richard C, Fryer Anthony A
Abstract excerpt
Maternal factors including atopy and smoking during pregnancy are associated with asthma risk during childhood. Suggested mechanisms include transmission of specific maternal alleles and maternal influences on the intrauterine environment. We have previously shown that polymorphism in glutathione S-transferase, GSTP1 is associated with airway hyperresponsiveness (AHR) and atopy in adults. We now hypothesise that...
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