Article
Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children.
Thorax - 1 Mar 2009
Islam T, Berhane K, McConnell R, Gauderman W J, Avol E, Peters J M, Gilliland F D
Abstract excerpt
BACKGROUND: Because asthma has been associated with exercise and ozone exposure, an association likely mediated by oxidative stress, we hypothesised that glutathione-S-transferase (GST)P1, GSTM1, exercise and ozone exposure have interrelated effects on the pathogenesis of asthma. METHODS: Associations of the well characterised null variant of GSTM1 and four single nucleotide polymorphisms (SNPs) that...
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