Article
The role of GSTP1 polymorphisms and tobacco smoke exposure in children with acute asthma.
The Journal of asthma : official journal of the Association for the Care of Asthma - 1 Nov 2010
Schultz En Nee, Devadason Sunalene G, Khoo Siew-Kim, Zhang Guicheng, Bizzintino Joelene A, Martin Andrew C, Goldblatt Jack, Laing Ingrid A, Le Souëf Peter N, Hayden Catherine M
Abstract excerpt
BACKGROUND: The glutathione S-transferase enzymes (GSTs) play an important role in the detoxification of environmental tobacco smoke (ETS), which contributes to airway inflammation, a key component of asthma. Genetic variation in GST genes may influence individuals' ability to detoxify environmental pollutants. OBJECTIVE: To examine the role of polymorphisms in GSTP1 (Ile105Val and Ala114Val), alone and in...
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