Article
Polymorphism at the glutathione S-transferase GSTP1 locus. A new marker for bronchial hyperresponsiveness and asthma.
American journal of respiratory and critical care medicine - 1 May 2000
Fryer A A, Bianco A, Hepple M, Jones P W, Strange R C, Spiteri M A
Abstract excerpt
Most genetic studies of asthma have concentrated on genes on chromosomes 11q and 5q and their association with the key asthma-related phenotypes of bronchial hyperresponsiveness (BHR) and atopy. Although asthma is characterized by airway inflammation, a critical component of which is oxidative stress, few data exist on genes involved in protecting against this insult. We describe an association study designed to...
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