Article
Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity state.
The Journal of biological chemistry - 21 Apr 2006
Salas Azucena, Shimaoka Motomu, Phan Uyen, Kim Minsoo, Springer Timothy A
Abstract excerpt
AlphaLbeta2 affinity for intercellular adhesion molecule-1 (ICAM-1) is regulated by the conformation of the alphaL I domain, which is in turn controlled by the conformation and orientation of other adjacent domains. Additionally, overall integrin conformation (bent versus straightened) influences the orientation of the I domain and access to its ligands, influencing adhesive efficiency. The open or high affinity...
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