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Article

Fox proteins are modular competency factors for facial cartilage and tooth specification.

Development (Cambridge, England) - 26 Jun 2018

Xu Pengfei, Balczerski Bartosz, Ciozda Amanda, Louie Kristin, Oralova Veronika, Huysseune Ann, Crump J Gage

Abstract excerpt

Facial form depends on the precise positioning of cartilage, bone, and tooth fields in the embryonic pharyngeal arches. How complex signaling information is integrated to specify these cell types remains a mystery. We find that modular expression of Forkhead domain transcription factors (Fox proteins) in the zebrafish face arises through integration of Hh, Fgf, Bmp, Edn1 and Jagged-Notch pathways. Whereas loss of...

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Identifiers

PMID: 29777011
DOI: 10.1242/dev.165498
PMCID: PMC6031403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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