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<i>Frem1</i> activity regulated by Sonic Hedgehog signaling in the cranial neural crest mesenchyme guides midfacial morphogenesis

2022-07-18

Abstract excerpt

The Frem/Fras family of extracellular matrix proteins has been linked to human face shape variation and malformation, but little is known about their regulation and biological roles in facial development. During midfacial morphogenesis in mice, we observed Frem1 expression in the embryonic growth centers that form the median upper lip, nose, and palate. Expansive spatial gradients of Frem1 expression in the cran...

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Literature Corpus work
863b0911-66e7-5076-a04d-b3e2dfebd96a
DOI
10.1101/2022.07.16.500318
Open publication

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<i>Frem1</i> activity regulated by Sonic Hedgehog signaling in the cranial neural crest mesenchyme guides midfacial morphogenesisDOI 10.1101/2022.07.16.500318
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