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Article

Sonic hedgehog regulation of Foxf2 promotes cranial neural crest mesenchyme proliferation and is disrupted in cleft lip morphogenesis.

Development (Cambridge, England) - 1 Jun 2017

Everson Joshua L, Fink Dustin M, Yoon Joon Won, Leslie Elizabeth J, Kietzman Henry W, Ansen-Wilson Lydia J, Chung Hannah M, Walterhouse David O, Marazita Mary L, Lipinski Robert J

Abstract excerpt

Cleft lip is one of the most common human birth defects, yet our understanding of the mechanisms that regulate lip morphogenesis is limited. Here, we show in mice that sonic hedgehog (Shh)-induced proliferation of cranial neural crest cell (cNCC) mesenchyme is required for upper lip closure. Gene expression profiling revealed a subset of Forkhead box (Fox) genes that are regulated by Shh signaling during lip...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28506991
DOI: 10.1242/dev.149930
PMCID: PMC5482988

Genes

FOXF2
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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