Article
Jagged-Notch signaling ensures dorsal skeletal identity in the vertebrate face.
Development (Cambridge, England) - 1 Jun 2010
Zuniga Elizabeth, Stellabotte Frank, Crump J Gage
Abstract excerpt
The development of the vertebrate face relies on the regionalization of neural crest-derived skeletal precursors along the dorsoventral (DV) axis. Here we show that Jagged-Notch signaling ensures dorsal identity within the hyoid and mandibular components of the facial skeleton by repressing ventral fates. In a genetic screen in zebrafish, we identified a loss-of-function mutation in jagged 1b (jag1b) that results...
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