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Article

A SHH-responsive signaling center in the forebrain regulates craniofacial morphogenesis via the facial ectoderm

27 Nov 2008

Abstract excerpt

Interactions among the forebrain, neural crest and facial ectoderm regulate development of the upper jaw. To examine these interactions, we activated the Sonic hedgehog (SHH) pathway in the brain. Beginning 72 hours after activation of the SHH pathway, growth within the avian frontonasal process (FNP) was exaggerated in lateral regions and impaired in medial regions. This growth pattern is similar to that in mice...

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PMID: 19036802
DOI: 10.1242/dev.026583

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