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Article

Targeting tumor cell plasticity by combined inhibition of NOTCH and MAPK signaling in colon cancer.

The Journal of experimental medicine - 4 Jun 2018

Schmidt Eva Marina, Lamprecht Sebastian, Blaj Cristina, Schaaf Christian, Krebs Stefan, Blum Helmut, Hermeking Heiko, Jung Andreas, Kirchner Thomas, Horst David

Abstract excerpt

In colorectal cancer, signaling pathways driving tumor progression are promising targets for systemic therapy. Besides WNT and MAPK signaling, activation of NOTCH signaling is found in most tumors. Here, we demonstrate that high NOTCH activity marks a distinct colon cancer cell subpopulation with low levels of WNT and MAPK activity and with a pronounced epithelial phenotype. Therapeutic targeting of MAPK...

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Source

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Identifiers

PMID: 29769248
DOI: 10.1084/jem.20171455
PMCID: PMC5987917

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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