Article

Notch3 regulates pericyte phenotypic plasticity in colorectal cancer

2025-06-07

Abstract excerpt

Pericytes undergo phenotypic alterations that influence cancer progression, yet the molecular mechanisms governing these changes remain poorly understood. Here, we investigated the role of Notch3 signaling in pericyte phenotype and functions in colorectal cancer (CRC). Using lineage tracing approaches, we showed that tumor pericytes originate from normal tissue-resident pericytes, which proliferate inside tumors....

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Literature Corpus work: 4254b2da-a85f-52ac-89dd-c72f3e27d44b
DOI: 10.1101/2025.06.04.657823

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