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Targeting Wnt Signaling in Colon Cancer Stem Cells

16 Dec 2010

Abstract excerpt

The identification of cancer stem cell (CSC) populations in virtually all tumor types has widespread clinical consequences. CSCs are suggested to be the only cells within malignancies endowed with tumorigenic capacity and are, therefore, directly implicated in therapy resistance and minimal residual disease. The genetic and molecular mechanisms sustaining CSCs are only currently emerging. For instance, aberrant...

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PMID: 21159886
DOI: 10.1158/1078-0432.ccr-10-1204

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