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Article

Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.

International journal of cancer - 15 Jul 2009

Zhang Hui-Hua, Walker Francesca, Kiflemariam Sara, Whitehead Robert H, Williams David, Phillips Wayne A, Mikeska Thomas, Dobrovic Alexander, Burgess Antony W

Abstract excerpt

Tumor-derived cell lines are indispensable tools for understanding the contribution of activated signaling pathways to the cancer phenotype and for the design and testing of targeted signal therapies. In our study, we characterize 10 colorectal carcinoma cell lines for the presence of mutations in the wnt, Ras/MAPK, PI3K and p53 pathways. The mutational spectrum found in this panel of cell lines is similar to...

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PMID: 19378335
DOI: 10.1002/ijc.24289

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APC
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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