Article
Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.
International journal of cancer - 15 Jul 2009
Zhang Hui-Hua, Walker Francesca, Kiflemariam Sara, Whitehead Robert H, Williams David, Phillips Wayne A, Mikeska Thomas, Dobrovic Alexander, Burgess Antony W
Abstract excerpt
Tumor-derived cell lines are indispensable tools for understanding the contribution of activated signaling pathways to the cancer phenotype and for the design and testing of targeted signal therapies. In our study, we characterize 10 colorectal carcinoma cell lines for the presence of mutations i...
Topics
- Base Sequence
- Cell Line, Tumor
- Cell Proliferation
- Colorectal Neoplasms
- DNA Primers
- Electrophoresis, Polyacrylamide Gel
- Genes, APC
- Humans
- Mutation
- Phosphorylation
- Polymerase Chain Reaction
- Proto-Oncogene Proteins B-raf
- Signal Transduction