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MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

16 May 2019

Abstract excerpt

In colorectal cancer (CRC), aberrant Wnt signalling is essential for tumorigenesis and maintenance of cancer stem cells. However, how other oncogenic pathways converge on Wnt signalling to modulate stem cell homeostasis in CRC currently remains poorly understood. Using large-scale compound screens in CRC, we identify MEK1/2 inhibitors as potent activators of Wnt/β-catenin signalling. Targeting MEK increases Wnt...

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PMID: 31097693
DOI: 10.1038/s41467-019-09898-0

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