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Article

An RNA interference phenotypic screen identifies a role for FGF signals in colon cancer progression.

PloS one - 1 Jan 2011

Leushacke Marc, Spörle Ralf, Bernemann Christof, Brouwer-Lehmitz Antje, Fritzmann Johannes, Theis Mirko, Buchholz Frank, Herrmann Bernhard G, Morkel Markus

Abstract excerpt

In tumor cells, stepwise oncogenic deregulation of signaling cascades induces alterations of cellular morphology and promotes the acquisition of malignant traits. Here, we identified a set of 21 genes, including FGF9, as determinants of tumor cell morphology by an RNA interference phenotypic screen in SW480 colon cancer cells. Using a panel of small molecular inhibitors, we subsequently established phenotypic...

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Identifiers

PMID: 21853123
DOI: 10.1371/journal.pone.0023381
PMCID: PMC3154943

Genes

FGF9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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