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Article

Notch3 regulates pericyte phenotypic plasticity in colorectal cancer.

Communications biology - 30 Jan 2026

Chalkidi Niki, Stavropoulou Athanasia, Arvaniti Vasiliki-Zoi, Paraskeva Christina, Monogyiou Artemis, Sakkou Maria, Nikolaou Christoforos, Koliaraki Vasiliki

Abstract excerpt

Pericytes, essential components of the tumor microenvironment, undergo phenotypic alterations that influence cancer progression, yet the molecular mechanisms governing these changes remain poorly understood. Here, we investigate the role of Notch3 signaling in pericyte phenotype and functions in colorectal cancer (CRC). Using lineage tracing approaches, we show that murine tumor pericytes originate from normal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41618002
DOI: 10.1038/s42003-026-09629-4
PMCID: PMC12960917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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