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Integrative Analysis of Genomics and Transcriptome Data to Identify Potential Functional Genes of BMDs in Females

8 Jan 2016

Abstract excerpt

Osteoporosis is known to be highly heritable. However, to date, the findings from more than 20 genome-wide association studies (GWASs) have explained less than 6% of genetic risks. Studies suggest that the missing heritability data may be because of joint effects among genes. To identify novel heritability for osteoporosis, we performed a system-level study on bone mineral density (BMD) by weighted gene...

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Bioinformatics and Genomic Networks
Bone health and osteoporosis research
Bone Metabolism and Diseases

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PMID: 26748680
DOI: 10.1002/jbmr.2781

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